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Ushering In The Harmony



“The day science begins to study non-physical phenomena, it will make more progress in one decade than in all the previous centuries of its existence.”

- Nikola Tesla


Within your inner ear is an organ called the "organ of Corti”, or Spiral Organ.


It not only receives sound, but light as well!


Biologically speaking, it represents the Golden Ratio/Spiral and there are genes coded to it that speak to the nature of our very existence.


This spiral organ communicates with a few notable genes called Harmonin, Usherin, and Whirlin, which we will discuss below.


The spiral organ is part of the inner ear that looks like a snail, which is the cochlea and it receives sound in the form of vibrations, which then causes tiny bundles on hair cells (stereocilia) to move and transmits nerve impulses that are sent to the brain to be interpreted as sounds.


The Spiral Snail, Apple In The Eye, Jacob's Ladder, & The Lifting of The Veil



The stereocilia, or Inner hair cells (IHCs) and outer hair cells (OHCs), orchestrate the signaling cascade that converts vibrations into electrical impulses that are sent to the brain to be interpreted as sound.


Research suggests that our harmonin gene plays a role in the development and maintenance of hairlike projections called stereocilia.


Stereocilia are basically our cellular antennas that pick up on frequency.


HARMONIN


Harmonizing LIGHT & SOUND.


The USH1C[1] gene carries the instructions for the production of a protein called harmonin[2].


Harmonin has the ability to bind to many other proteins in cell membranes and coordinates their activities. Harmonin sometimes acts as a bridge linking proteins in the cell membrane to those in the cytoskeleton, the internal framework that supports the cell.


Stereocilia line the inner ear and bend in response to sound waves.


This bending motion is critical for converting sound waves to nerve impulses, an essential process for normal hearing. In the inner ear, protein complexes organized by harmonin probably act as connectors that link stereocilia into a bundle.


This protein complex likely helps regulate the transmission of sound waves.

Harmonin is also made in specialized cells called photoreceptors.


These cells detect and transfer light energy to the light-sensitive tissue at the back of the eye (the retina).


TRPC5 (Transient Receptor Potential Cation Channel Subfamily C Member 5) plays a major role in the function of Harmonin through its Interactive DNA String Network.[3]


TRPC5 has been implicated in the mechanism of mercury toxicity and neurological behavior.[4]


So mercury may interfere with the “harmonizing” of light and sound information to the brain.


Another way to think about it is that mercury may cut you off from Source.


Compounds for TRPC5[5]:


· Daidzein (Kudzu root)

· Genistein (Nattokinase/Kudzu)

· Phosphatidylcholine (PC)


Harmonin also interacts with another gene called USHERIN[6], which we will discuss later on.


The WHIRLIN[7] gene is an important paralog to HARMONIN gene.


WHIRLIN


Whirl[8] means “to go round, spin”, as in the spiral spin of nature, or triskelion.


WHIRLIN[9] gene is thought to function in the organization and stabilization of stereocilia elongation and actin cytoskeletal assembly.


It’s also involved in hearing and vision and is necessary for elongation and maintenance of inner and outer hair cell stereocilia in the organ of Corti in the inner ear.


In retina photoreceptors, required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.


WHIRLIN interacts with a calmodulin-dependent serine kinase, CASK, and may be involved in the formation of scaffolding protein complexes that facilitate synaptic transmission in the central nervous system (CNS).[10]


The CASK gene[11] is a MAGUK (membrane-associated guanylate kinase) protein family member. These proteins are scaffold proteins and the encoded protein is located at synapses in the brain.


Compounds for CASK[12]:


· Magnesium

· Formic acid (Stinging Nettle)


Of note, Formic acid can be used as a fuel cell (it can be used directly in formic acid fuel cells and indirectly in hydrogen fuel cells).[13]


The MYO15A Gene also plays a major impact on Whirlin and Harmonin.

Unconventional Myosin-15 (MYO15A) is necessary for actin organization in the hair cells of the cochlea. Malfunctions in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness.[14]


The Antioxidant Action of Vitamin-C is mentioned in relation to Unconventional Myosin-15 (MYO15A).


USHERIN


Usherin is an important component of basement membranes, which are thin, sheet-like structures that separate and support cells in many tissues. Usherin is found in basement membranes in the inner ear and in the retina, which is the layer of light-sensitive tissue at the back of the eye. Studies suggest that it is part of a group of proteins (a protein complex) that plays an important role in the development and maintenance of cells in the inner ear and retina. The protein complex may also be involved in the function of synapses, which are junctions between nerve cells where cell-to-cell communication occurs.[15]


In the inner ear, required for the maintenance of the hair bundle ankle formation, which connects growing stereocilia in developing cochlear hair cells. In retina photoreceptors, the USH2 complex is required for the maintenance of periciliary membrane complex that seems to play a role in regulating intracellular protein transport.[16]


An important paralog of this gene is LAMA1.


Laminin Subunit Alpha 1 is also known as LAMA.[17]


LAMA means[18]:


· Superior one

· Chief, high priest

· Mud

· Wet meadow, marsh

· Torch, light

· Ancient

The LAMA gene is a major component of the basement membrane and has been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth, and metastasis.


It’s involved with Microglia Activation During Neuroinflammation.


Laminin is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.


Affected individuals have ataxia, delayed motor development, language impairment, and intellectual disability with variable severity.[19]


KEAP1 plays a major impact on LAMA through its Interactive DNA String Network.[20]


Keap1 has been shown to interact with Nrf2, a master regulator of the antioxidant response, which is important for the amelioration of oxidative stress.[21]


Because Nrf2 activation leads to a coordinated antioxidant and anti-inflammatory response, and Keap1 represses Nrf2 activation, Keap1 has become a very attractive drug target.


Glutathione-deficient cells that are highly susceptible to oxidative stress.


Nei Homolog 2 (NEIL2 Gene) is an important factor for the regulation of KEAP1 through its Interactive DNA String Network.[22]


Nei means[23]:


· No

· Negative particle

· Plural of Neo, meaning I spin; weave, interlace, entwine[24]


So the negative particle helps weave the spin of the spiral!


Nei Homolog 2 (NEIL2 Gene) helps initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break.[25]


It is primarily associated with DNA repair during transcription and acts preferentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine.


In other words, Uridine 5’ Monophosphate (UMP) for 5-hydroxyuracil and Cytidine-5’-diphosphate (CDP-Choline) for 5-hydroxycytosine may help to assist Nei Homolog 2 (NEIL2 Gene).


Compounds for NEIL2 Gene[26]:


· Copper

· Ferrous ascorbate

· Ferrous fumarate

· Ferrous gluconate

· Ferrous glycine sulfate

· Ferrous succinate

· Iron


Magnetite

Magnetite[27] is a rock mineral and one of the main iron ores. It is one of the oxides of iron, and is ferrimagnetic; it is attracted to a magnet and can be magnetized to become a permanent magnet itself.


It is the most magnetic of all the naturally-occurring minerals on Earth!


Naturally-magnetized pieces of magnetite, called lodestone, will attract small pieces of iron, which is how ancient peoples first discovered the property of magnetism.


If frequency determines physiology, which it does, then Ushering in the Harmonizing Whirl of the Spiral is paramount.


Biological occurrences


Biomagnetism is usually related to the presence of biogenic crystals of magnetite, which occur widely in organisms, including humans, where magnetite crystals (and other magnetically-sensitive compounds) are found in different organs, depending on the species.


Several species of birds are known to incorporate magnetite crystals in the upper beak for magnetoreception, which (in conjunction with cryptochromes in the retina) gives them the ability to sense the direction, polarity, and magnitude of the ambient magnetic field.

https://cosmosmagazine.com/wp-content/uploads/2020/02/071215_Bird-Compass_H-1440x464.jpg


Chitons, a type of mollusk, have a tongue-like structure known as a radula, covered with magnetite-coated teeth, or denticles. The hardness of the magnetite helps in breaking down food, and its magnetic properties may additionally aid in navigation.


Biological magnetite may store information about the magnetic fields the organism was exposed to, potentially allowing scientists to learn about the migration of the organism or about changes in the Earth's magnetic field over time.


Human brain


Living organisms can produce magnetite.


In humans, magnetite can be found in various parts of the brain including the frontal, parietal, occipital, and temporal lobes, brainstem, cerebellum, and basal ganglia.


Iron can be found in three forms in the brain – magnetite, hemoglobin (blood) and ferritin (protein), and areas of the brain related to motor function generally contain more iron.


Magnetite can be found in the hippocampus. The hippocampus is associated with information processing, specifically learning and memory.


However, magnetite can have toxic effects due to its charge or magnetic nature and its involvement in oxidative stress or the production of free radicals.


Research suggests that beta-amyloid plaques and tau proteins associated with neurodegenerative disease frequently occur after oxidative stress and the build-up of iron.


How to possibly address iron overload yet still get the advantages of magnetite


A special quality of Yellow Dock is that it greatly enhances the body's ability to absorb iron.


Yellow Dock is excellent for making iron available to the body. Yellow Dock may be used to clear blockages and cut binding ties that prevent one from moving on. It can help eliminate emotional waste that accumulates as garbage and is lugged around as a burden. It helps one deal with and release emotions tied to problems of the past, anxieties and old pain. Yellow Dock can help open the practitioner to new influences and clears the boundaries between inner and outer space. It is a good herb for periods of transition and transformation at the cusp to a new phase in life.


Some researchers also suggest that humans possess a magnetic sense, proposing that this could allow certain people to use magnetoreception for navigation.


Electron microscope scans of human brain-tissue samples are able to differentiate between magnetite produced by the body's own cells and magnetite absorbed from airborne pollution, the natural forms being jagged and crystalline, while magnetite pollution occurs as rounded nanoparticles.


Potentially a human health hazard, airborne magnetite is a result of pollution (specifically combustion). These nanoparticles can travel to the brain via the olfactory nerve, increasing the concentration of magnetite in the brain.


In some brain samples, the nanoparticle pollution outnumbers the natural particles by as much as 100:1, and such pollution-borne magnetite particles may be linked to abnormal neural deterioration.


In one study, the characteristic nanoparticles were found in the brains of 37 people: 29 of these, aged 3 to 85, had lived and died in Mexico City, a significant air pollution hotspot. A further eight, aged 62 to 92, came from Manchester, and some had died with varying severities of neurodegenerative diseases.


According to researchers led by Prof. Barbara Maher at Lancaster University and published in the Proceedings of the National Academy of Sciences, such particles could conceivably contribute to diseases like Alzheimer's disease. Though a causal link has not been established, laboratory studies suggest that iron oxides like magnetite are a component of protein plaques in the brain, linked to Alzheimer's disease.


This is why combining Yellow Dock with Ferrous (iron) compounds is vital!


Increased iron levels, specifically magnetic iron, have been found in portions of the brain in Alzheimer's patients.


Monitoring changes in iron concentrations may make it possible to detect the loss of neurons and the development of neurodegenerative diseases prior to the onset of symptoms due to the relationship between magnetite and ferritin.


In tissue, magnetite and ferritin can produce small magnetic fields that will interact with magnetic resonance imaging (MRI) creating contrast. Huntington patients have not shown increased magnetite levels; however, high levels have been found in study mice.


The presence of magnetite in humans, however, also has other potential implications, including possible biological disorders linked to the weak magnetic fields generated by cellular phones, electric power lines, and appliances, or high-field saturation effects from exposure to strong magnetic fields during MRI procedures.


At the same time, nanoparticles of magnetite are of special interest in the biomedical sciences, because they can be used as carriers for targeted drug delivery.


Moreover, magnetite nanoparticles can be exploited for hyperthermia-based cancer therapy, where the heat-induced by application of an alternating magnetic field causes necrosis of cancer cells but does not damage the surrounding normal tissue.


Various researchers have further proposed that endogenous magnetite might play a key role in perception, transduction, and long-term storage of information in the human brain and in other organisms.


The occurrence of magnetite in cell tissues, therefore, represents an intriguing dichotomy: On the one hand, the mineral can play a key role in magnetoreception and navigation, and thus survival, of various types of organisms, and on the other hand, it can impart deleterious effects in humans, especially when they are exposed to high PM concentrations in polluted urban environments.[28]


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Sources:

[1] https://www.genecards.org/cgi-bin/carddisp.pl?gene=USH1C [2] https://en.wikipedia.org/wiki/Usher_1C [3] https://version11.string-db.org/cgi/network.pl?taskId=Pn3jcRDOWxqK [4] https://en.wikipedia.org/wiki/TRPC5 [5] https://www.genecards.org/cgi-bin/carddisp.pl?gene=TRPC5#drugs_compounds [6] https://www.genecards.org/cgi-bin/carddisp.pl?gene=USH2 [7] https://www.genecards.org/cgi-bin/carddisp.pl?gene=WHRN [8] https://en.wiktionary.org/wiki/whirl#English [9] https://ghr.nlm.nih.gov/gene/WHRN [10] https://en.wikipedia.org/wiki/DFNB31 [11] https://www.genecards.org/cgi-bin/carddisp.pl?gene=CASK [12] https://www.genecards.org/cgi-bin/carddisp.pl?gene=CASK&keywords=cask#drugs_compounds [13] https://en.wikipedia.org/wiki/Formic_acid [14] https://www.genecards.org/cgi-bin/carddisp.pl?gene=MYO15A [15] https://ghr.nlm.nih.gov/gene/USH2A [16] https://www.genecards.org/cgi-bin/carddisp.pl?gene=USH2A [17] https://www.genecards.org/cgi-bin/carddisp.pl?gene=LAMA1 [18] https://en.wiktionary.org/wiki/lama [19] https://ghr.nlm.nih.gov/gene/LAMA1#conditions [20] https://version11.string-db.org/cgi/network.pl?taskId=rEr3jRdvQlGD [21] https://en.wikipedia.org/wiki/KEAP1 [22] https://version11.string-db.org/cgi/network.pl?taskId=eTPNkrv3hNAw [23] https://en.wiktionary.org/wiki/nei [24] https://en.wiktionary.org/wiki/neo [25] https://en.wikipedia.org/wiki/NEIL2 [26] https://www.genecards.org/cgi-bin/carddisp.pl?gene=NEIL2#drugs_compounds [27] https://en.wikipedia.org/wiki/Magnetite


[28] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5087066/

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