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Artemis, The MAGI, Temple of the gods, The Great Pyramid, Energy Transduction & Viral Transfection

All bodily systems are controlled by the electrical system. We are in fact a hydro-electric machine. The flow of information in the central and autonomic nervous system, the brain and spinal cord, operation of muscles, and organs to control and maintain billions of electrical signals have to be generated in the human nervous system.


A bio-energetic field may also be generated from outside mechanical forces that are then transferred into biochemical signals that impact cell-cell signaling, protein-protein interactions, and consequently can either be beneficial or deleterious to overall health.


Electromagnetic waves have the capability to hijack a person’s brain and nervous system and subvert an individual’s sense of control over their own thinking, behavior, emotions or decision making.


See:


US Electromagnetic Weapons and Human Rights


Mind Control with Electromagnetic Frequency

Everything on this planet carries a distinct energy and frequency pattern that can be measured, such as herbs. Therefore, viruses, bacteria, and stealth pathogens also carry unique signatures. This opens up the possibility of an electric signal to be used to transfect. Essentially inserting a foreign agent, via frequency, and corrupting the geometric field creating a disequilibrium within our nervous system, which then carries that signal throughout the body. The cells then respond according to the input and cannot make the distinction.


When we think about the flow of energy (transduction) and the capacity of viral infection (transfection), there are three major genes at play that communicate with one another:


· Ret Proto-Oncogene (Rearranged During Transfection), or RET

· Glial Cell Derived Neurotrophic Factor (GDNF)

· Artemin (ARTN)



This research will tie language, history, mythology, and health into one subject and we will break down each subject and wrap them together. Although these subjects may seem unconnected at first glance, they are not. When we begin to unravel these complex topics and connect the dots we can begin to see patterns emerge and a new realm of therapeutic interventions emerge. You may wish to read this several times. Often times we are taught to separate topics such as discussed herein when in fact the universe works in a synergistic fashion as all things are connected.


To make a life system dynamically stable and sustainable, it needs to involve a huge amount of atoms and molecules working in synchronization. In general, a life system utilizes both electrical and chemical carriers for inner communication. Molecules carrying chemical information, such as hormones, move slowly in a liquid environment of a living system. Therefore, for fast activities such as the motion of a body, electrical signals are usually the only choices for message carriers.


See: Wireless Communication in Biosystems


Before getting into some of the science behind these genes and pathways let us discuss the use of language as it applies to the etymology of naming genes because it then opens up a whole new realm of possibilities.

Artemis


Artemin etymology: From Latin Artemisia, from Ancient Greek ἀρτεμισία (artemisia), from Ἄρτεμις (Artemis, “Artemis, the goddess”).[1]


Artemis is related either to Greek αρτεμης (artemes) meaning "safe" or αρταμος (artamos) meaning "a butcher".[2]


ARTEMIS WAS NAMED AS A GOD OF THE HUNT


Consequently, Artemis is also known as the goddess of Fertility.


Artemis Networks


Artemis Networks[3] is also a wireless 5G company that utilizes pWave rapid 5G deployment.


pWave™ radios transmit signals that deliberately interfere with each other, combining to synthesize tiny pCells, each just one cm in size.


Every mobile device has its own pCell™, a “personal cell,” each getting the full spectrum capacity.


pCell technology is all about harnessing and combining radio signals, even interference to create extra wireless energy around each individual mobile device that follows the device (YOU) wherever it goes.


One could say that Artemis hunts you wherever you go!

https://assets.website-files.com/52f04b50d6dbc2930f000490/5866ec20870773086f875295_3cell_pcell-art-pcells.png

https://assets.website-files.com/52f04b50d6dbc2930f000490/586d619c4b7da7443a5180b3_Cityscape.jpg


The graphics icon on the website of one of the biggest "killer-app" 5G device manufacturers & installers.

https://upload.wikimedia.org/wikipedia/en/thumb/a/a3/Artemis_Networks_logo.png/220px-Artemis_Networks_logo.png


Upon looking at the Artemis logo we see the resemblance of a Triskelion symbol.

https://upload.wikimedia.org/wikipedia/commons/thumb/9/99/Coa_Illustration_Cross_Triquetra.svg/220px-Coa_Illustration_Cross_Triquetra.svg.png


So what’s the connection between Artemis and the Triskelion?


Artemis' deer...The Sarna!

Sarna


Sarna Definition: (Polish) Dweller at the sign of the roe deer; one thought to possess some of the qualities of a roe deer; one who came from Sarnay (place where deer were found).[4]


Sarna also stands for Small activating RNAs (saRNAs).[5]


Small activating RNAs (saRNAs) small double-stranded RNAs (dsRNAs) that target gene promoters to induce transcriptional gene activation in a process known as RNA activation (RNAa).


Protein Argonaute-2 is one such saRNA.[6]


This “Argonaute gene”, as in Jason and the Argonauts[7], is important for antiviral defense against multiple viruses.[8]


Among its related pathways are Downstream signaling events of B Cell Receptor (BCR) and RET signaling (Rearranged During Transfection).


The Sarna Triskelion

https://cfw.sarna.net/wiki/images/thumb/d/d8/Triskelion.jpg/191px-harkravdkmy6wgn713b5uwox9bo0zcc.jpg?timestamp=20151228022709


This image is a battle action figure in a game created in 1984. In it is what's described for this battle action figures use of weapons and equipment which makes a clear connection for the use of Artemis and the use of the Triskelion.


Weapons and Equipment[9]


The Triskelion's Guardian ECM Suite is used for basic electronic warfare protection.

Each launcher also features an advanced Artemis V Fire Control System, which improves the hit ratio of the missiles hitting the Triskelion's targets.


So…do you see the connection between Artemis, the Triskelion, and 5G?


The new Artemis 5G company improves the electromagnetic frequency hit ratio (directed signal). It would also appear that the triskelion (Clathrin) provides protection from electronic warfare.


Very quickly, Clathrin is a protein in our body that forms the ancient triskelion symbol.


Clathrin requires Mannose to function correctly in order to provide basic electronic warfare protection, as stated above in the video game related to Sarna.


Mannose 6-Phosphate Receptors Regulate the Formation of Clathrin-coated Vesicles in the TGN.[10]


Wormwood


Artemis also lent her name to the Artemisia, a genus of plants whose members were used in a variety of herbal and medicinal preparations. The genus was so named because analgesics made from the plants were used by midwives, and Artemis was a goddess of midwifery. Besides the analgesics, Artemisia plants made up the wormwood used in absinthe as well as Artemisinin, a compound that was used in treatment for malaria.[11]


What do we find when we cross-reference “Artemisinin + EMF”?


Henry Lai (scientist)[12]


Henry Lai is a scientist, researcher and bioengineering Professor Emeritus at the University of Washington and Editor-in-chief of Electromagnetic Biology and Medicine. Lai published research in 1995 that concluded that low-level microwave radiation caused DNA damage in rat brains.


Lai and a fellow researcher, Narendra “N.P.” Singh, were looking at the effects of nonionizing microwave radiation the same type of radiation emitted by cell phones on the DNA of rats. They used a level of radiation considered safe by government standards and found that the DNA in the brain cells of the rats was damaged—or broken by exposure to the radiation.

Funded initially by the Office of Naval Research, Lai was investigating how radar, which emits radio-frequency radiation, affects the health of operators. “We did not really pay attention to the importance of this thing,” he recalls. But during his research, cell phone company Motorola Inc. indicated that someone had told the company about Lai’s unpublished results. Motorola asked to meet with him in his lab and at a meeting in Copenhagen.


Lai and Singh have published research on the effects of artemisinin on cancer.


Lai and Singh claim that Motorola attempted to discredit their low-level microwave radiation findings in order to suppress them. Lai and Singh further argue that cell phone proponents have funded their own research to confuse the subject and mitigate the influence of independent research results while suppressing further research perceived as harmful to the cell phone industry. Motorola has denied suppressing Lai's research.


UW Scientist Henry Lai Makes Waves in the Cell Phone Industry[13]

http://www.seattlemag.com/sites/default/files/field/image/0111_cellulardamage_0.jpg


Thus was launched an epic battle over research and truth. If Lai and Singh were correct about the potential impact on brain cells from radio-frequency radiation, there could be billions of dollars on the line for the cell phone industry in potential liability, leading to significant design changes and lost market expansion.


We’re not doing research at all,” Lai says. With government funding all but nonexistent, the bulk of scientific research is funded by private industry. “The mechanism is funding,” Lai says. “You don’t bite the hand that feeds you. The pressure is very impressive.”


Dr. Beth Mueller, an epidemiologist at the Fred Hutchinson Cancer Research Center in Seattle, acknowledges that there is not strong evidence linking cell phones to brain tumors. But Mueller warns that the research is difficult and that much more study is needed. “I think [cell phone radiation] would be important to study. There are no studies I know of on the possible impact on children and I think it’s something that many people–including some people here at the Hutch–want to see evaluated. I’m concerned because children are using [cell phones] a lot. It’s something that should be looked at, definitely.”


Radiations and male fertility study[14]


The study concludes that the RF-EMF may induce oxidative stress with an increased level of reactive oxygen species, which may lead to infertility. This has been concluded based on available evidences from in vitro and in vivo studies suggesting that RF-EMF exposure negatively affects sperm quality.


Effect of electromagnetic field exposure on the reproductive system[15]


The effects of electromagnetic fields on the number of ovarian primordial follicles: An experimental study[16]


This study found a significant decrease in the number of ovarian follicles in rats exposed to an EMF. Further clinical studies are needed to reveal the effects of EMFs on ovarian reserve and infertility.


Radiations and female fertility study[17]


Electromagnetic Field Exposure Effects (ELF-EMF and RFR) on Fertility and Reproduction[18]

The Artemis Gene


ARTN Gene[19]


Artemin (ARTN) encodes a secreted ligand of the glial cell line-derived neurotrophic factor (GDNF) subfamily and TGF-beta (transforming growth factor-beta) superfamily of proteins.


Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression.


This protein signals through the RET receptor and GFR alpha 3 coreceptor, and supports the survival of a number of peripheral neuron populations and at least one population of dopaminergic CNS neurons. This protein has also been shown to promote tumor growth, metastasis, and drug resistance in mammary carcinoma.


Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.

https://www.mdpi.com/ijms/ijms-19-01078/article_deploy/html/images/ijms-19-01078-g001-550.jpg


Glial cell line-derived neurotrophic factor (GDNF) and TGF-beta (transforming growth factor-beta) mainly regulate Artemin gene.


So, if we want to regulate the “goddess of the hunt” gene we must modulate GDNF and TGF-beta.


GDNF Agonist:

· Ashwagandha[20]

· Vitamin A[21]

· Flavonoids[22]

· Kudzu[23]


TGF-β Antagonist:

· PPAR gamma agonists[24]

· Klotho[25]

· Ursolic acid[26] (Prunella Vulgaris)

· Betulinic acid[27] (Prunella Vulgaris)

· Fucoidan[28]

· Resveratrol[29]

· Zinc[30]

· Sea buckthorn[31]

· Kudzu[32]

The MAGI


GDNF Family Receptor Alpha 1 (GFRA1 Gene) is highly associated with RET and ARTN in which they share a common SuperPathway:


G-protein signaling_H-RAS regulation pathway SuperPath


Of particular interest in this pathway is a gene called MAGI1.[33]

The etymology of MAGI[34]:


magi (n.)

c. 1200, "skilled magicians, astrologers," from Latin magi, plural of magus "magician, learned magician," from Greek magos, a word used for the Persian learned and priestly class as portrayed in the Bible (said by ancient historians to have been originally the name of a Median tribe), from Old Persian magush "magician" (see magic). Also, in Christian history, the "wise men" who, according to Matthew, came from the east to Jerusalem to do homage to the newborn Christ (late 14c.). Related: Magian.


MAGI-1 is a member of the membrane-associated guanylate kinase homologue (MAGUK) family.


MAGI-1 may regulate acid-induced ASIC3 currents by modulating its expression at the cell surface. More on this later.


MAGI-1 is, in part, regulated by the RALA gene.[35]-[36]


The etymology of RALA[37]:


· Ruined state an ingot (esp. of silver or gold)

· The resin of the Sāla tree

· A cricket

· Ruined, spoiled, marred, blasted, disgraced, disconcerted

· Components, parts or elements are separated more than usual in their class[38].


The Sal Tree[39]


In Hindu tradition, the sal tree is said to be favored by Vishnu. Its name shala, shaal or sal, comes from Sanskrit (शाल, śāla, literally "house").

Perhaps RALA means the “breaking down of the house, or the breaking down of fat, or the manipulation of metals?”


In India, the tree is sacred to Hindus, who believe its hooded flowers look like the nāga, and it is grown at Shiva temples.

Of note and a topic for another time, we do have a gene called Shiva, who was the destroyer, which is related to apoptosis (cell death) to which the naga was affiliated.


In Hinduism, the Nāga or Nagi are divine, semi-divine deities, or a semi-divine race of half-human half-serpent beings that reside in the netherworld and can occasionally take human form.

https://en.wikipedia.org/wiki/N%C4%81ga#/media/File:6th_century_coiled_Nagaraja_in_ceiling_(cave_1),_Badami_Hindu_cave_temple_Karnataka.jpg


Sometimes the word nāgá is also used generically to mean "snake". The nāgas are described as the powerful, splendid, wonderful, and proud semidivine race that can assume their physical form either as human, partial human-serpent or the whole serpent. Their domain is in the enchanted underworld, the underground realm filled with gems, gold, and other earthly treasures called Naga-loka or Patala-loka. They are also often associated with bodies of waters — including rivers, lakes, seas, and wells (possibly the fountain of youth connected to the tree of life) — and are guardians of treasure.


It would appear that both positive and negative entities connected to ancient religions both had access to this. Just as an electric signal may be used to harm, or to heal.


And yes, we do have a gene called NAGA. NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase. An important paralog of this gene is GLA. Among its related pathways are Innate Immune System and Sphingolipid metabolism.


Compounds for NAGA gene: glucosamine 6-phosphate, or N-Acetyl Glucosamine (NAG).


Compounds for Galactosidase Alpha (GLA gene): Mannose and Fatty acids such as Sea buckthorn and Coconut derivitives.


Perhaps the Naga gave "ruined" gold to the Magi? Or, perhaps the Magi were the Naga themselves? These hoarders of "ruined" gold and their assistance of the breaking down of the house, or RALA, our spiritual temples. In any event, there is much to be explored on this topic.


Their power and venom made them potentially dangerous to humans. However, they often took a beneficial protagonist role in Hindu mythology, such as in Samudra manthan mythology, Vasuki, a nāgarāja who abides on Shiva's neck, became the churning rope for churning of the Ocean of Milk. Their eternal mortal enemies are the Garudas, the legendary semidivine birdlike-deities.


Moreover, nagas are sometimes linked to medicine. Owing to the naga Shesha's presence in Hindu legend's Samudra manthan of which Dhanvantari (god of Indic medicine) and Amrit (healing potion) were created alongside the universe, the nagas are thus linked to medicine in some extents. The nagas can also be founded substituting the snakes in either Rod of Asclepius or mistakenly Caduceus of several medical institutions' symbols. The former seal of Faculty of Medicine, Srinakharinwirot University, and the seal of Society of Medical Student Thailand are some notable examples using the Caduceus with nagas presence instead of snake.


The flag of the World Health Organization, with a rod of Asclepius

https://en.wikipedia.org/wiki/Rod_of_Asclepius#/media/File:Flag_of_WHO.svg


The emergency services 'Star of Life' features a rod of Asclepius


The samudra manthana explains the origin of amrita, the nectar of immortality.


So The MAGI are connected to the Sal Tree and Gold, which is connected to the NAGA, which is then connected to the Nectar of Immortality. All of which is connected to the Tree of Life and the Fountain of Youth.


Also according to Buddhist tradition, the Buddha was lying between a pair of sal trees when he died.


In Buddhism, the brief flowering of the sal tree is used as a symbol of impermanence[40] and the rapid passing of glory.


Impermanence, also known as the philosophical problem of change, are temporal things, whether material or mental, that are compounded objects in a continuous change of condition, subject to decline and destruction.


Human life embodies this flux in the aging process, the cycle of repeated birth and death, nothing lasts, and everything decays. The breaking down of the house, or physical body.


“As long as there is attachment to things that are unstable, unreliable, changing and impermanent, there will be suffering – when they change, when they cease to be what we want them to be. If craving is the cause of suffering, then the cessation of suffering will surely follow from 'the complete fading away and ceasing of that very craving': its abandoning, relinquishing, releasing, letting go.”


Nothing lasts, everything is in constant state of change! But, some change – mental, or physical, or self-knowledge – leads to happiness and therefore need to be sought for liberation!


Impermanence can also mean everything flows, such as energy. Heraclitus was famous for his insistence on ever-present change as being the fundamental essence of the universe, as stated in the famous saying, "No man ever steps in the same river twice". The philosophical concept of becoming, as contrasted with "being".

"whatever is, is, and what is not cannot be"


Sal tree resin is known as sal dammar[41]. Dammar gum is a triterpenoid resin, containing many triterpenes and their oxidation products. Many of them are low molecular weight compounds (dammarane, dammarenolic acid, oleanane, oleanonic acid, etc.) Gum Dammar resin (white) (Shorea wiesneri) from Indonesia is also known as 'cat-eye resin', which is said to lift the spirit and bring light to the darkness of the soul. Dammar resin is particularly useful to combat sadness, depression and melancholy.


The RALA gene also communicates with HRAS/KRAS.[42]


KRAS etymology:


Polish: from kras ‘beauty’, ‘good looks’, a nickname for a handsome person (see Krasny). Dutch: nickname from Old French cras ‘fat’[43] (Fat assists in the regulation of Piezo1)


KRAS is also a form of the word Karst[44]:


A type of land formation, usually with many caves formed through the dissolving of limestone by underground drainage.


Piezoelectricity


Piezoelectricity is the electric charge that accumulates in certain solid materials (such as crystals, certain ceramics, and biological matter such as bone, DNA, and various proteins.


This is precisely how an external signal is converted into a biochemical reaction within your body!


In terms of the Piezoelectric effect and our DNA we actually have a gene called Piezo1 and Piezo2, of which the Piezo1 gene has the alias of Mib[45].


Mib etymology[46]:


Perhaps a corruption of marble.


Marble etymology[47]:


· To become interlaced with fat.

· A rock of crystalline limestone.


An interesting note is that the Great Pyramids were crafted of carved-out giant limestone.

The Great Pyramid of Giza is constructed with approximately 2,300,000 limestone and granite blocks.


So what do limestone and fat equate to?


Natural hydraulic lime (NHL) is produced by heating (calcining) limestone that naturally contains clay and other impurities. Hydraulic lime concretes have been in use since Roman times.


An example is the Pantheon in Rome, which has survived for nearly two thousand years. The dome's diameter is equal to its height from the floor. It is constructed from six different lime mixes, which change the properties and lightness of the material.


The Pantheon in Rome: temple of all Gods.[48]

Godfrey and Hemsoll maintain that the word Pantheon "need not denote a particular group of gods, or, indeed, even all the gods, since it could well have had other meanings. Certainly the word pantheus or pantheos, could be applicable to individual deities. Bearing in mind also that the Greek word θεῖος (theios) need not mean 'of a god' but could mean 'superhuman', or even 'excellent'.


Using what's known as Phonetics...Pantheon sounds extremely similar to pantothenic!


Pantothenic acid, also called vitamin B5 (a B vitamin), is a water-soluble vitamin. Pantothenic acid is an essential nutrient. Animals require pantothenic acid in order to synthesize coenzyme-A (CoA), as well as to synthesize and metabolize proteins, carbohydrates, and fats.[49]


Its name derives from the Greek pantothen, meaning "from everywhere", and small quantities of pantothenic acid are found in nearly every food.


Pantothenic acid is used in the synthesis of coenzyme A (CoA). Coenzyme A may act as an acyl group carrier to form acetyl-CoA and other related compounds; this is a way to transport carbon atoms within the cell. CoA is important in energy metabolism for pyruvate to enter the tricarboxylic acid cycle (TCA cycle) as acetyl-CoA, and for α-ketoglutarate to be transformed to succinyl-CoA in the cycle.


CoA is also important in the biosynthesis of many important compounds such as fatty acids, cholesterol, and acetylcholine. CoA is incidentally also required in the formation of ACP, which is also required for fatty acid synthesis in addition to CoA.


PPAR signaling pathway is a major pathway associated with acyl carrier protein (ACP).

PPAR requires Medium Chain Fatty Acids[50] like Palmitic acid, Myristic acid and Capric acid, etc., Sea buckthorn and Coconut derivatives.


Acyl carrier protein (ACP) also requires FAD (Vitamin B1/B2).


These genes and pathways surrounding the aforementioned also require NAD/NADPH (vitamin B1, B2, B3/CoQ10, and Carnitine).


Resveratrol has also been shown to upregulate NAD biosynthesis.[51]


So when we combine Vitamins B1, B2, B3, B5, CoQ10, Carnitine with Seabuckthorn, Coconut derivatives, Acetylcholine, Resveratrol, and Cholesterol agents, like Dan shen, will we may be able to obtain “superhuman”, or “super health” benefits!?

So how does the “MAGI” manifests electronic currents or transduction?

The MAGI - PIEZO Connection


Acid Sensing Ion Channels (ASICs)


Acid-sensing ion channels (ASICs) are neuronal voltage-insensitive sodium channels activated by extracellular protons permeable to Na+. ASIC1 also shows low Ca2+ permeability.[52]


ASIC proteins are a subfamily of the ENaC/Deg (Epithelial sodium channel) superfamily of ion channels.


They are typically found in both the central nervous system and peripheral nervous system.


The role of the ASIC is to sense reduced levels of extracellular pH and result in a response or signal from the neuron.


All ASICs are specifically permeable to sodium ions. Voltage-gated Ca2+ channels are activated resulting in an influx of calcium into the cell. This causes depolarization of the neuron and an excitatory response released. In ASIC1a, Ca2+ increase inside the cell is a result of calcium influx directly through the channel.


Protein kinase A (PKA) and Protein kinase C (PKC) help regulate ASIC function through phosphorylation.


N-linked glycans and N-glycosylation also play a MAJOR role.[53]


Hello Glycoimmunology: ignore at your peril!


Acid-sensing ion channel-1a (ASIC1a), the major proton receptor in the brain, is a potential therapeutic target for multiple neurological diseases. Brain acidosis, or a reduction in extracellular brain pH, leads to neuronal damage in multiple neurological diseases.

ASIC1a also regulates neuronal firing and synaptic plasticity, and contributes to seizure termination. Of note, ASIC1a contributes to multiple diseases, including stroke, multiple sclerosis, and seizures; all generate ER stress.


N-linked glycosylation

https://upload.wikimedia.org/wikipedia/commons/thumb/a/a0/Variety_of_glycans.svg/440px-Variety_of_glycans.svg.png


Mannose, N-Acetyl Glucosamine (GlcNAc), and Fucose (Fucodian/Bladderwrack) play the MAJOR role in this process!

ASIC2 regulates the PIEZO1 Gene.[54]-[55]


Piezo genes are mechanically-activated ion channels that link mechanical forces to biological signals[56]. Plays a key role in blood vessel formation and vascular structure in both development and adult physiology.


Malfunctioning Piezo channels may lead to hemolytic anemia characterized by primary erythrocyte dehydration, both of which reflect cellular dehydration. Loss of potassium from red cells and increased red cell trapping in the spleen and elevated bilirubin levels, respectively also occur.


Swelling of body parts due to developmental anomalies and functional defects of the lymphatic system may also occur with recurrent local infections.



“Control the geometry; control the biology.” – Joey Phillips

Piezo and Clathrin, through the Triskelion, share the same exact geometry!


More on Clathrin below…

Transfection and Transduction


In terms of energy transduction here are a few key things to consider…


First, the words Transfection and Transduction are used interchangeably.


Transfection is the process of deliberately introducing naked or purified nucleic acids into eukaryotic cells.[57]


Transduction is the process by which foreign DNA is introduced into a cell by a virus or viral vector. Transduction with viral vectors can be used to insert or modify genes in mammalian cells.


The definition of Transduction[58] (trans- + -duc- + -tion, "leading through or across") can refer to:


· Signal transduction, any process by which a biological cell converts one kind of signal or stimulus into another.

· Transduction (biophysics), the conveyance of energy from a donor electron to a receptor electron, during which the class of energy changes.

· Transduction (physiology), the transportation of stimuli to the nervous system.

· A process by which a transducer converts one type of energy to another.


Signal transduction


Physiology. The intercellular or intracellular transfer of information (biological activation/inhibition) through a signal pathway. In each signal transduction system, an activation/inhibition signal from a biologically active molecule (hormone, neurotransmitter) is mediated via the coupling of a receptor/enzyme to a second messenger system or to an ion channel. Signal transduction plays an important role in activating cellular functions, cell differentiation, and cell proliferation.


Electromagnetic fields and public health


The use of electricity has become an integral part of everyday life. Whenever electricity flows, both electric and magnetic fields exist close to the lines that carry electricity and close to appliances. Since the late 1970s, questions have been raised whether exposure to these extremely low frequency (ELF) electric and magnetic fields (EMF) produces adverse health consequences.[59] Exposure to a 50 Hz Electromagnetic Field Induces Activation of the Epstein-Barr Virus Genome in Latently Infected Human Lymphoid Cells[60]


Alterations of genome-wide methylation and DNMTs expression may play an important role in the biological effects of 50 Hz ELF-EMF exposure[61]


Cytosine methylation - The latency of several pathogenic viruses e.g., Epstein-Barr, herpes, HIV, is maintained by cytosine methylation.[62]


Epigenetic Regulation of HIV-1 Latency by Cytosine Methylation[63]

As we can see, there is a clear correlation between nEMF exposure and viral activation that impacts cytosine methylation primarily through DNMT1 and MECP2[64].

https://www.wikipathways.org/index.php/Pathway:WP3584


MECP2 (methyl-CpG binding protein 2) is in many mammals an important regulator of neuronal function and development. It affects all cell types, especially neurons but also astrocytes, oligodendrocytes, and glial cells.


Malfunctions impairing the proper function of MECP2 are mainly associated with the Rett syndrome but may also contribute to other neurological disorders like schizophrenia, FASD (fetal alcohol syndrome), PPM-X-syndrome, autism, Prader-Will-syndrome, and Angelman-syndrome.[65]


And that RET “Rearranged During Transfection gene” and Cytosine methylation are connected[66].

RET Gene - Ret Proto-Oncogene


RET is also known as the “Rearranged During Transfection” gene.


The RET gene provides instructions for producing a protein that is involved in signaling within cells. This protein appears to be essential for the normal development of several kinds of nerve cells, including nerves in the intestine (enteric neurons) and the portion of the nervous system that controls involuntary body functions such as heart rate (the autonomic nervous system). The RET protein is also necessary for normal kidney development and the production of sperm (spermatogenesis).[67]


Nerves transmit what? Electric signals.


The RET protein spans the cell membrane, so that one end of the protein remains inside the cell and the other end projects from the outer surface of the cell. This positioning of the protein allows it to interact with specific factors outside the cell and to receive signals that help the cell respond to its environment.


Withaferin A (Ashwagandha) has been shown to impact RET. Withaferin A is a novel natural-product RET-inhibitor.[68]

Keepers of the Gate


In Greek mythology, the 'Orai' are the keepers of the gates of heaven: Eunomia (order or harmony), Dike (justice) and Eirene (peace).[69]


Withaferin A is also an Orai1 inhibitor.[70]


This “Gatekeeper” gene also influences PI3k/AKT/ERK signaling[71], which we will discuss below, as RET signaling has a major impact on PI3K-MTOR-AKT-MEK pathways as well.

The Triskelion Gatekeeper


STIM1/ORAI1 colocalize with clathrin[72] (triskelion) which helps determine clathrin-mediated endocytosis.[73]


Again, Clathrin forms a Triskelion shape. A clathrin cage with a single triskelion highlighted in blue.

https://upload.wikimedia.org/wikipedia/commons/thumb/9/93/Clathrin_cage_viewed_by_croelectron_microscopy.jpg/220px-Clathrin_cage_viewed_by_croelectron_microscopy.jpg

STIM1/ORAI1 is specifically linked to clathrin-mediated endocytosis.


Coat-proteins, like clathrin, are used to build small vesicles in order to transport molecules within cells. The endocytosis and exocytosis of vesicles allows cells to communicate, to transfer nutrients, to import signaling receptors, to mediate an immune response after sampling the extracellular world, and to clean up the cell debris left by tissue inflammation. The endocytic pathway can be hijacked by viruses and other pathogens in order to gain entry to the cell during infection.

https://www.mechanobio.info/wp-content/uploads/2018/02/YangYang2017.jpg


The triskelion creates a bioelectric and biomagnetic energy flow based on mathematics and sacred geometry. This is the “Spiral of Life”.

It has an amazing ability to neutralize harmful energy.


Watch the energetic movement within a triskelion in this video.


The Triskelion also forms the C-60 Fullerene.



As receivers and transmitters, triskelions made of certain metals gather and disseminate the frequencies at which they resonate. The triskelion has an amazing ability to neutralize harmful energy, balancing yin and yang, (positive and negative; masculine and femine) in almost any setting.


Mannose 6-Phosphate Receptors Regulate the Formation of Clathrin-coated Vesicles.[74]


Mannose 6-Phosphate Receptors require Mannose, the “Manna”. The root of both "mannose" and "mannitol" is manna.[75]


The Peyer's patch


RET helps promote the formation of Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue.[76]


Peyer's Patches: The Immune Sensors of the Intestine.[77]


Because the lumen of the gastrointestinal tract is exposed to the external environment, much of it is populated with potentially pathogenic microorganisms. Peyer's patches thus establish their importance in the immune surveillance of the intestinal lumen and in facilitating production of the immune response within the mucosa.[78]


Model of Peyer's patch development

https://www.researchgate.net/figure/Model-of-Peyers-patch-development-Peyers-patch-development-relies-on-a-multi-step_fig2_230574327

Overexposure to toxins and EMF alters the Peyer’s patch[79], which then burdens the immune system.


Radiation-induced injury also induces rapid loss of the integrity of the epithelial layer lining the intestines. This results in poor resorption of nutrients and fluids in the gut and loss of the intestine's barrier function.[80]


Phosphorylated mannanoliglaueosaccharides (MOS) act beneficially since they modulate the immune response of animals by presenting the pathogen to Peyer's patches. Pathogens and toxins associated with MOS form a great blend that is easily identified by the immune system.[81]


Mannan may refer to a plant polysaccharide that is a linear polymer of the sugar mannose.[82]


Detection of mannan leads to lysis in the mannan-binding lectin pathway[83]. This mannan is the source of MOS used as prebiotics in animal husbandry and nutritional supplements.


This lectin pathway starts with mannose-binding lectin (MBL) or ficolin binding to certain sugars.


Mannan-binding lectin, also called mannose-binding protein, is a protein belonging to the collectin family that is produced by the liver and can initiate the complement cascade by binding to pathogen surfaces.


RET has a MAJOR influence on GDNF (glial cell derived neurotrophic factor).


GDNF encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene.


GDNF is a neurotrophic factor that enhances survival and morphological differentiation of dopaminergic neurons and increases their high-affinity dopamine uptake.

Compounds for GDNF Gene - From: DrugBank, PharmGKB, ClinicalTrials, HMDB, and Novoseek[84]:


· Chondroitin sulfate


Other GDNF compounds:

· Ashwagandha[85]

· Vitamin A[86]

· Flavonoids[87] - Luteolin, Quercetin, Kaempferol, Myricetin, Isoflavonoids (Genistein/Nattokinase, Daidzein/Kudzu).[88]


Glial cell line-derived neurotrophic factor (GDNF) family, consisting of GDNF, neurturin, artemin and persephin are distant members of the transforming growth factor-beta (TGF-beta) superfamily.


GDNF also recruits Ret to the lipid rafts and triggers association with Src, which is required for effective downstream signalling, leading to differentiation and neuronal survival. GDNF family ligands are potent survival factors for midbrain dopamine neurons, motoneurons, noradrenergic neurons, as well as for sympathetic, parasympathetic and sensory neurons.[89]


SRC proto-oncogene, non-receptor tyrosine kinase[90]


Non-receptor protein tyrosine kinase which is activated following engagement of many different classes of cellular receptors including immune response receptors, integrins and other adhesion receptors, receptor protein tyrosine kinases, G protein-coupled receptors as well as cytokine receptors. Participates in signaling pathways that control a diverse spectrum of biological activities including gene transcription, immune response, cell adhesion, cell cycle progression, apoptosis, migration, and transformation. Plays an important role in the regulation of cytoskeletal organization through phosphorylation of specific substrates such as AFAP1, which is involved with the Immune response IFN gamma signaling pathway.[91]-[92]


When cells adhere via focal adhesions to the extracellular matrix, signals are transmitted by integrins into the cell resulting in tyrosine phosphorylation of a number of focal adhesion proteins, including PTK2/FAK1 and paxillin (PXN).


In addition to phosphorylating focal adhesion proteins, SRC is also active at the sites of cell-cell contact adherens junctions and phosphorylates substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1), and plakoglobin (JUP).

Another type of cell-cell junction, the gap junction, is also a target for SRC, which phosphorylates connexin-43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing and phosphorylates RNA-binding proteins such as KHDRBS1.

Also plays a role in PDGF-mediated tyrosine phosphorylation of both STAT1 and STAT3, leading to increased DNA binding activity of these transcription factors.


Involved in the RAS pathway through phosphorylation of RASA1 and RASGRF1.


Plays a role in EGF-mediated calcium-activated chloride channel activation.

Required for epidermal growth factor receptor (EGFR) internalization through phosphorylation of clathrin heavy chain (CLTC and CLTCL1).


Involved in beta-arrestin (ARRB1 and ARRB2) desensitization through phosphorylation and activation of GRK2, leading to beta-arrestin phosphorylation and internalization.

Has a critical role in the stimulation of the CDK20/MAPK3 mitogen-activated protein kinase cascade by epidermal growth factor.


Might be involved not only in mediating the transduction of mitogenic signals at the level of the plasma membrane but also in controlling progression through the cell cycle via interaction with regulatory proteins in the nucleus.


Plays an important role in osteoclastic bone resorption in conjunction with PTK2B/PYK2. Both the formation of a SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for this function. Recruited to activated integrins by PTK2B/PYK2, thereby phosphorylating CBL, which in turn induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function.

Promotes energy production in osteoclasts by activating mitochondrial cytochrome C oxidase.


Phosphorylates DDR2 on tyrosine residues, thereby promoting its subsequent autophosphorylation.


Phosphorylates RUNX3 and COX2 on tyrosine residues, TNK2, and CBL.

Enhances DDX58/RIG-I-elicited antiviral signaling.


Phosphorylates PDPK1. Phosphorylates BCAR1. Phosphorylates CBLC at multiple tyrosine residues, phosphorylation activates CBLC E3. Involved in anchorage-independent cell growth. Required for podosome formation.


Consequently, podosomes are present in cell types associated with tissue remodeling and the immune system.[93]


Src kinases consist of eight non-receptor tyrosine kinases (Src, Fyn, Yes, Lck, Lyn, Hck, Fgr and Blk) that interact with the intracellular domains of growth factor/cytokine receptors, GPCRs and integrins.[94]


Compounds for SRC Gene - From: DrugBank, ClinicalTrials, ApexBio, DGIdb, HMDB, Tocris, and Novoseek:


· Citric acid

· Kaempferol


Other mechanisms of action involved with compounds surrounding SRC:


· SRC/BCR-ABL tyrosine kinase inhibitors - Zinc[95], Magnesium[96], Resveratrol[97], Genistein[98], Quercetin[99], Luteolin[100], Licorice[101], Ginger[102], Skullcap[103], Rosmarinic acid[104], Dan shen/Sage[105].


· AURORA Kinase Inhibitors - Resveratrol[106], Salvia Miltiorrhiza (Red Sage)[107]


· Fibroblast growth factor receptor (FGFR) inhibitors - Klotho Agonist[108]: Resveratrol[109], Chondroitin sulfate[110], Glucosamine[111], Beta Glucan[112], Vitamin K2 (Nattokinase)[113], Oleanoic acid[114], Sea buckthorn[115], Dan shen[116], Kaempferol[117], Coconut[118], Bladderwrack[119], Zinc[120], Selenium[121], Vitamin C, Vitamin E, Proline[122], Phosphatidylcholine[123].


· PDGFR Kinase Inhibitors - Pomegranate[124]


· VEGF receptor inhibitors - Pomegranate[125], Resveratrol[126], Anthocyanins[127] (Prunella vulgaris), Luteolin[128], Kaempferol[129], Myricetin[130] (Sea buckthorn)


· Hsp90 inhibitor – Resveratrol[131], Withaferin A / Ashwagandha[132], Genistein[133] (Nattokinase/Kudzu), Vinpocetine[134], Quercetin[135], Phosphatidylcholine[136], Ellagic acid (Pomegranate)[137], Zinc[138], Betulinic acid (Prunella vulgaris).[139]


· GSK-3 INHIBITOR – Prunella vulgaris[140].


· SYK INHIBITOR – Resveratrol, Dan shen, Ginger, Licorice, Skullcap.[141]

In summary, the compounds listed above may help assist the body in the regulation of Viral Transfection & Transduction helping to bring the body into homeostasis through these highly complex systems involved with energy fluctuations.


This is intended for education, research and data collection. These statements have not been evaluated by the Food and Drug Administration. This product/service is not intended to diagnose, treat, cure, or prevent any disease. The information provided on this site is for informational purposes only and is not intended as a substitute for advice from your physician or other health care professional or any information contained on or in any product label or packaging. You should not use the information on this site for diagnosis or treatment of any health problem or for prescription of any medication or other treatment. You should consult with a healthcare professional before starting any diet, exercise or supplementation program, before taking any medication, or if you have or suspect you might have a health problem. You are solely responsible for doing your own research on any information provided. The "Protocol" is strictly based on a "what I would do if I were you" scenario. This Site, Service, and Protocol should not substitute professional advice. Individual results may vary. Database references herein are not all inclusive. Getting well from reading or using the information contained herein is purely coincidental. Any and all products or services may be subject to change.


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